PolyPhil™ polynucleotide treatment

PolyPhil™ Polynucleotide Treatment

A PolyPhil PN-HPT® treatment is designed to naturally stimulate the skin to regenerate and rejuvenate. PolyPhil™ contains a revolutionary and powerful bioregenerative ingredient: polynucleotides. Key factors that determine skin quality include elasticity, texture, hydration, and an even tone. The clinically proven polynucleotide skin booster treatment improves the skin on all of these levels. In this article, you’ll discover everything about PolyPhil™ treatments: what it is, how it works, what to expect, and how to find the best clinics in the UAE via Injectablesbooking.

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What are polynucleotides?

In recent years, the medical cosmetic industry has seen a shift towards natural beauty and healthy ageing. A natural look combined with optimal, healthy skin quality is becoming increasingly popular. These trends have sparked growing interest in regenerative skin treatments and introduced a new player in the aesthetics field that is gaining international popularity among both practitioners and clients: polynucleotides (PN).

On platforms like Instagram and TikTok, you may have seen this trend referred to as “salmon sperm injections.” Thanks in part to beauty revelations from celebrities like Kim Kardashian and Jennifer Aniston, interest in the benefits of polynucleotide treatments has grown significantly. The term “salmon sperm treatment” is misleading, as it does not involve salmon sperm. The treatment actually uses a bioregenerative ingredient: polynucleotides (PN)—small fragments of DNA that play a crucial role in cell regeneration and repair. They consist of long chains of nucleotides, which are the natural “building blocks” of the skin.

What is a PolyPhil™ polynucleotide treatment?

PolyPhil™ is classified as a skin booster treatment. Skin boosters are injectable products designed to naturally stimulate the skin’s regeneration and rejuvenation. PolyPhil™ contains a revolutionary and powerful bioregenerative ingredient: polynucleotides (PN). When injected into the skin, polynucleotides effectively “switch on” certain natural skin repair processes, providing a safe and natural way to rejuvenate the skin.

Polynucleotides PN-HPT® work on multiple levels, offering a variety of benefits for the skin, including: Stimulating fibroblasts (increasing both the number and viability of fibroblasts), Promoting collagen and elastin production, which improves skin texture and elasticity, Supporting tissue repair and wound healing, Enhancing hydration, Providing antioxidant effects.

Clinically proven effectiveness

Are polynucleotides new? Not at all! The regenerative potential of polynucleotides has been recognised and used in wound care for decades. Polynucleotides have a clinically proven safety and efficacy profile, with high tolerability and a low risk of side effects, supported by over 70 years of research and more than 100 published studies.

What makes the PolyPhil™ polynucleotide skin booster so special?

PolyPhil™ polynucleotides stand out due to a unique combination of advanced technology, high-quality ingredients, and strict adherence to European production and safety standards. The polynucleotides in PolyPhil™ are naturally derived (from salmon trout) and undergo a patented high-purification process known as PN-HPT® (‘PolyNucleotides – High Purification Technology’). This technology, combined with controlled production in Europe according to GMP quality standards, ensures the high safety and consistent quality of the PolyPhil™ skin booster. All components of PolyPhil™ are biocompatible and fully resorbable, meaning no residue remains in the skin (unlike cross-linked HA fillers). The result is a safe, natural anti-ageing treatment with a very low risk of side effects, suitable for all ages and skin types.

A multitasker for the skin

Did you know that PN-HPT® polynucleotides have a fourfold action?

1.      stimulate and activate fibroblasts

2.      promote hydration

3.      increase collagen synthesis

4.      provide antioxidant effects by neutralising free radicals

Thanks to this, the PolyPhil™ skin booster is highly versatile, suitable not only for the face and delicate eye area but also for the neck, décolleté, hands, abdomen, scalp, and more. Because of the fourfold mechanism of action, a PolyPhil™ treatment can be used for a wide range of purposes beyond general skin rejuvenation, improving skin texture, elasticity, and hydration. These include: Enhancing overall skin tone (e.g., redness, pigment irregularities), Reducing dark circles under the eyes, Scar treatment (including acne scars, eyelid correction scars, stretch marks), Addressing certain hair growth issues.

PolyPhil™ also has a synergistic effect with other aesthetic treatments, such as laser therapy, radiofrequency (RF), fillers, chemical peels, microneedling, and surgical procedures, potentially helping to shorten recovery time. The PolyPhil™ range includes four skin boosters with relatively high concentrations of polynucleotides, tailored to specific skin needs and indications. Consult your doctor to explore the potential of the PolyPhil™ skin booster and to create a personalised treatment plan.

How does a PolyPhil™ treatment work?

Every medical cosmetic treatment begins with a thorough consultation with a qualified and experienced doctor. During this consultation, your medical history, any allergies, previous aesthetic procedures, and your wishes and expectations for the treatment are carefully discussed.

Treatment sessions: Typically, a series of three sessions is recommended, spaced 2–3 weeks apart, to achieve optimal results.

The PolyPhil™ polynucleotides are injected into the skin using very small, superficial injections (multi-puncture technique) with an ultra-fine needle. The treatment usually takes 15–30 minutes, depending on the area being treated. Mild side effects may occur, such as temporary bumps/swelling, bruising, or redness at the injection points, which generally resolve within a few hours to a few days.

Polynucleotides stimulate and enhance the skin’s natural regeneration processes, meaning it can take a few weeks for the full results to become visible. However, improved hydration and a healthy “glow” can often be seen quickly.

To maintain results, it is recommended to repeat the treatment regularly (for example, every six months). Your doctor will advise you based on your individual case. The following factors can influence how long the effects last:

• Lifestyle (diet, sleep, stress, smoking)

• Exposure to UV light

• Age

• Overall skincare routine

Benefits of a PolyPhil™ treatment

·       Improved hydration: Polynucleotides enhance the skin’s natural ability to retain moisture, resulting in a more hydrated and youthful appearance.

·       Cell regeneration: The treatment supports the repair and regeneration of skin cells (including collagen synthesis), improving overall skin condition.

·       Enhanced skin texture: PolyPhil™ improves skin texture, reducing the appearance of large pores, acne scars, and other imperfections, leaving skin softer and smoother.

·       Under-eye improvement: Particularly effective for the delicate under-eye area, helping to reduce fine lines, puffiness, and dark circles.

·       Anti-inflammatory properties: Polynucleotides have anti-inflammatory effects, which can help reduce redness and rosacea, resulting in a more even skin tone.

·       Free radical protection: Their antioxidant properties can help address sun damage and pigmentation irregularities.

·       Safety: PolyPhil™ is highly biocompatible, with a very low risk of side effects.

·       Natural results: Unlike traditional fillers, PolyPhil™ does not add volume but improves overall skin condition, texture, and elasticity, for a natural-looking result.

·       Skin “primer”: Enhances the results of other treatments (fillers, peels, laser, eyelid surgery, etc.) thanks to its synergistic effect.

·       Clinically proven technology: Safe and effective, suitable for all skin types and ages.

·       Minimal downtime: As a non-invasive treatment, you can resume daily activities almost immediately.

Cost of a PolyPhil™ treatment

Costs can vary depending on several factors, including the clinic, the experience of the doctor, the area being treated (how much product is required), and whether the treatment is offered as a single session, a multi-session package, or as part of a combination treatment. On average, prices in the UAE range from approximately AED 1,500 to AED 2,100 per session.

Through Injectablesbooking, you can easily find a clinic near you and choose an option that suits your needs and budget.

Sources:

1 Collangelo MT. Govoni P, Beletti s, Squadrito F, Guizzardi S, Galli C. Polynucleotide biogel enchances tissue repair, matrix desposition and organization. J. of Biological Regulators & Homeostatic Agents. 2021;Vol35(1):355-362.

2 Bartoletti E, Cavallini M, Maioli L, Massirone A, Palmieri IP, Papagni M et al. Introduction to Polynucleotides Highly Purified Technology. Aesthetic Medicine.2020 Oct-Dec;Vol.7(1):43-47.

3 Cavallini M, Papagni M. Long Chain Polynucleotides Gel and Skin Biorevitalization. International Journal of Plastic Dermatology-ISPLAD. 2007; 3(3): 27-32

4 Araco A, Araco F. Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne Scars. Aesthet Surg J. 2021 Jun 14;41(7):NP866-NP874. doi: 10.1093/asj/sjab125. PMID: 33755110.

5 Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M et al. Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021 Mar;20(3): 922-928. doi: 10.1111/ jocd.13679. Epub 2020 Sep 21. PMID: 32799391; PMCID: PMC7984045.

6 Massirone A. Polynucleotides Highly Purified Technology and the face skin, a history of innovative skin priming. Aesthetic Medicine.2021 Jan-Mar ;Vol.7(1): 25-40.